{"id":2293,"date":"2019-08-12T01:50:18","date_gmt":"2019-08-12T05:50:18","guid":{"rendered":"http:\/\/atlanticurologyclinics.com\/?p=2293"},"modified":"2020-04-13T12:54:17","modified_gmt":"2020-04-13T16:54:17","slug":"xiaflex-for-peyronies-disease","status":"publish","type":"post","link":"https:\/\/atlanticurologyclinics.com\/featured-treatments\/xiaflex-for-peyronies-disease\/","title":{"rendered":"Xiaflex for Peyronie’s Disease"},"content":{"rendered":"\t\t
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What is XIAFLEX\u00ae?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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XIAFLEX\u00ae<\/sup>\u00a0is a prescription medicine used to treat adult men with Peyronie\u2019s disease who have\u00a0a “plaque”that can be felt and a curve in their penis greater than 30 degrees when treatment is started. It is not known if XIAFLEX\u00ae<\/sup>\u00a0is safe and effective in children under the age of 18.<\/p>

XIAFLEX\u00ae<\/sup>\u00a0is a\u00a0nonsurgical treatment\u00a0that can be given in a urologist’s office. It is an injection that works to weaken and break down the\u00a0plaque that is causing your erect penis to curve.<\/p>

Along with\u00a0gentle stretching and straightening of your penis, XIAFLEX\u00ae<\/sup>\u00a0may be able to help improve your erectile curvature caused by\u00a0Peyronie’s disease.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"XIAFLEX-1\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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*Based on approximately 21,000 patients, receiving on average approximately 5.1 vials each over their treatment course, between December 2013 and November 14, 2017. Injections performed are estimated based on the number of vials sold.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Clinical trial results: curvature<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Results from 2 large clinical studies for XIAFLEX\u00ae<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Men received either up to 4 treatment cycles of XIAFLEX\u00ae<\/sup>\u00a0with penile modeling, or placebo injection with penile modeling*, and then were observed until 52 weeks.<\/p>

The goal of 2 large clinical studies involving more than 500 patients was to:<\/p>

  • Measure the change in erectile curvature from the beginning of the study to Week 52<\/li>
  • Measure the change in the Bother domain score from the beginning of the study to Week 52<\/li>
  • Evaluate\u00a0safety<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\"pdpat_pages_how_xiaflex_helps_chart\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Improvement in erectile curvature<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    STUDY 1<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    In the first study, men who received XIAFLEX\u00ae<\/sup>\u00a0and penile modeling had an average change in their erectile curvature from the beginning of the study to Week 52 of 35%, compared with 18% in men who had placebo injection with penile modeling*<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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    STUDY 2<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    In the second study, men who received XIAFLEX\u00ae<\/sup> and penile modeling had an average change in their erectile curvature from the beginning of the study to Week 52 of 33%, compared with 22% in men who had placebo injection with penile modeling (no medicine)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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    Images represent a 33% improvement<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\"XIAFLEX-baseline\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\"XIAFLEX-change\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    XIAFLEX\u00ae<\/sup>\u00a0was not associated with shortening of penile length in clinical trials in the treatment of Peyronie’s disease<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    Clinical trial results: patient Bother<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Patients in the studies were asked to answer questions from the Bother section of the Peyronie’s Disease Questionnaire (PDQ) at the beginning and end (Week 52) of the studies. This is known as the Bother domain score. The Bother domain score is a\u00a0total score<\/strong>\u00a0from answers related to the following items:<\/p>

    • Concern about how erection looks<\/li>
    • Concern about erection pain<\/li>
    • Impact of Peyronie\u2019s disease on frequency of intercourse<\/li>
    • Impact of Peyronie\u2019s disease on intercourse<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Improvement in bother scores from the PDQ<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      STUDY 1<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      In the first study, men who received XIAFLEX\u00ae<\/sup> and penile modeling had an average reduction in their Bother domain scores of 37% from the beginning of the study to Week 52, compared with 22% in men who had placebo injection with penile modeling (no medicine)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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      STUDY 2<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      In the second study, men who received XIAFLEX\u00ae<\/sup> and penile modeling had an average reduction in their Bother domain scores of 35% from the beginning of the study to Week 52, compared with 18% in men who had placebo injection with penile modeling (no medicine)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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      Treatment with XIAFLEX\u00ae<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      XIAFLEX\u00ae<\/sup>\u00a0is the only FDA-approved,\u00a0nonsurgical treatment option<\/strong>\u00a0for appropriate patients with Peyronie’s disease. You can receive XIAFLEX\u00ae<\/sup>\u00a0right in your healthcare professional’s (HCP) office.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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      You and your HCP will participate in 2 equally important parts of your treatment<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      \n\t\t\t\t\t\t\t\t\t\t\t\t\t\"getting-treated-treatment-injection-of-xiaflex\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Helps weaken and break down Peyronie’s plaque<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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      \n\t\t\t\t\t\t\t\t\t\t\t\t\t\"getting-treated-treatment-penile-modeling\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Gentle stretching and straightening activities help reduce erectile curvature and straighten the penile shaft<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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      A treatment course of XIAFLEX\u00ae consists of up to 4 treatment cycles approximately 6 weeks apart<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Set up all injection appointments at the initial consultation. Your HCP will determine how many treatment cycles are appropriate.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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      \n\t\t\t\t\t\t\t\t\t\t\t\t\t\"xiaflex-treatment-cycles-chart-desktop\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      XIAFLEX\u00ae is a prescription medicine used to treat adult men with Peyronie\u2019s disease.<\/p>\n","protected":false},"author":2,"featured_media":2294,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[14,22],"tags":[33],"careers":[],"yoast_head":"\nXiaflex for Peyronie's Disease | Atlantic Urology Clinics<\/title>\n<meta name=\"description\" content=\"XIAFLEX is a nonsurgical treatment that can be given in a urologist\u2019s office. It is an injection that works to break down the plaque that causes issues.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/atlanticurologyclinics.com\/featured-treatments\/xiaflex-for-peyronies-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Xiaflex for Peyronie's Disease | Atlantic Urology Clinics\" \/>\n<meta property=\"og:description\" content=\"XIAFLEX is a nonsurgical treatment that can be given in a urologist\u2019s office. 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